BiP inducer X

Research use only, not for human use.

BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.

BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.(In Vitro):Pretreatment of BiP inducer X (5?μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5?μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.(In Vivo):In male adult ddY mice, BiP inducer X (20?μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction.

BIX

Apoptosis

Apoptosis

NFAT5

——

——

101714-41-4

209.2

C9H7NO3S

>98% (HPLC)

——

Oc1ccc(cc1O)C(=O)CSC#N

——

(-20℃)

With Ice Pack

≥ 2 years